Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
---|---|---|---|---|---|---|---|---|
ELMI002169 | P51170 SCNN1G SCNNG_HUMAN |
624 | 627 | GTQVPGTPPPKYNTLRLERA | TP | --- | Homo sapiens (Human) | 649 |
Instance evidence
Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
---|---|---|---|---|---|---|---|
experimental | MI:0007 | anti tag coimmunoprecipitation | in vivo | Zhou,2007 | support | certain | InteractionDetection |
experimental | MI:0256 | rna interference | in vivo | Zhou,2007 | support | certain | InteractionDetection |
experimental | MI:0997 | ubiquitinase assay | in vitro | Zhou,2007 | support | certain | InteractionDetection |
experimental | MI:0074 | mutation analysis | in vivo/in vitro | Zhou,2007 | support | certain | FeatureDetection |
experimental | MI:0113 | western blot | in vitro | Zhou,2007 | support | certain | ParticipantIdentification FeatureDetection |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000323:
Phosphorylation of Isoform Nedd4-2a of E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) by Serine/threonine-protein kinase Sgk1 (SGK1) induces binding to 14-3-3 protein eta (YWHAH). This inhibits (whether allosterically or sterically is not known) interactions of NEDD4L via its WW domains with the PY motif in Amiloride-sensitive sodium channel subunit gamma (SCNN1G) (ENaC). As a result, ENaC does not get degraded and ENaC-mediated Na+ currents increase.
Pathways
KEGG: The sequence P51170 is implicated in the following 2 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement