ELM - instance LIG_SH3_3 in sequence P06729 at position 294

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002165	P06729 CD2 CD2_HUMAN	294	300	HRSQAPSHRPPPPGHRVQHQ	TP	---	Homo sapiens (Human)	351

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0077	nuclear magnetic resonance	in vitro	Freund,2002	support	certain	InteractionDetection FeatureDetection
experimental	MI:0405	competition binding	in vitro	Freund,2002	support	certain	InteractionDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000337:

T-cell surface antigen CD2 (CD2) uses overlapping motifs to bind to CD2 antigen cytoplasmic tail-binding protein 2 (CD2BP2) and Fyn, which makes their interactions mutually exclusive. Since CD2BP2 and Tyrosine-protein kinase Fyn (FYN) reside in different subcellular locations, the specificity of CD2 for the two competitors is switched by changing its cellular localization, from non-raft membranes to lipid raft membranes.

Pathways

KEGG: The sequence P06729 is implicated in the following 2 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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