| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI002145 | O95644 NFATC1 NFAC1_HUMAN |
238 | 245 | GSPRHSPSTSPRASVTEESW | TP | --- | Homo sapiens (Human) | 943 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0424 | protein kinase assay | in vivo | Sheridan,2002 | support | certain | InteractionDetection |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Sheridan,2002 | support | certain | FeatureDetection |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000012:
Phosphorylation of S245 adjacent to the NLS of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) by cAMP subfamily primes Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) for subsequent phosphorylation by Glycogen synthase kinase-3 beta (GSK3B), which results in inhibition of nuclear import of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1).
Pathways
- AGE RAGE signaling pathway in diabetic complications
- B cell receptor signaling pathway
- C type lectin receptor signaling pathway
- Cellular senescence
- Hepatitis B
- Human T cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Inflammatory bowel disease
- Kaposi sarcoma associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- Oxytocin signaling pathway
- PD L1 expression and PD 1 checkpoint pathway in cancer
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP PKG signaling pathway
Please cite:
The Eukaryotic Linear Motif resource: 2022 release.
(PMID:34718738)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement