The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI002133 P07766 CD3E
CD3E_HUMAN
184 188 KERPPPVPNPDYEPIRKGQR TP 2ROL  
Homo sapiens (Human) 207

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0096 pull down in vivo/in vitro Kesti,2007 support likely InteractionDetection
experimental MI:0084 phage display Kesti,2007 support likely InteractionDetection
experimental MI:0081 peptide array Kesti,2007 support likely InteractionDetection
experimental MI:0007 anti tag coimmunoprecipitation in vivo Kesti,2007 support likely InteractionDetection
experimental MI:0005 alanine scanning in vivo/in vitro/in silico Kesti,2007 support likely FeatureDetection
experimental MI:0065 isothermal titration calorimetry in vitro Aitio,2008 support certain InteractionDetection
experimental MI:0077 nuclear magnetic resonance in vitro Aitio,2008 support certain InteractionDetection FeatureDetection
experimental MI:0519 glutathione s tranferase tag in vitro Kesti,2007 support certain
experimental MI:0034 display technology in vivo/in vitro Kesti,2007 support certain InteractionDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Kesti,2007 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Kesti,2007 support certain FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q12929) EPS8_HUMAN IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues
531 590 [mitab][xml]
(Q8TE68) ES8L1_HUMAN IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues
478 537 24.0/24.0 [mitab][xml]
(Q9H6S3) ES8L2_HUMAN IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues
492 551 [mitab][xml]
(Q8TE67) ES8L3_HUMAN IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues
450 509 [mitab][xml]
(P16333) NCK1_HUMAN IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues
2 61 8.2/8.4 [mitab][xml]
(O43639) NCK2_HUMAN IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues
2 61 [mitab][xml]

o  Pathways

KEGG: The sequence P07766 is implicated in the following 11 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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