ELM - instance LIG_PDZ_Class_2 in sequence P18827 at position 305

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002122	P18827 SDC1 SDC1_HUMAN	305	310	PKQANGGAYQKPTKQEEFYA	TP	---	Homo sapiens (Human)	310

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0096	pull down	in vivo/in vitro		support	certain	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Sulka,2009	support	certain
experimental	MI:0074	mutation analysis	in vivo/in vitro	Sulka,2009	support	certain	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000199:

Phosphorylation of Y309 in the PDZ-binding motif of Syndecan-1 (SDC1) prevents binding to the PDZ domain of Syntenin-1 (SDCBP), an interaction involved in the formation of cellular protrusions.

Pathways

KEGG: The sequence P18827 is implicated in the following 5 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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