| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI002020 | P40763 STAT3 STAT3_HUMAN |
724 | 729 | TCSNTIDLPMSPRTLDSLMQ | TP | --- | Homo sapiens (Human) | 770 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0096 | pull down | in vivo/in vitro | support | certain | InteractionDetection | |
| experimental | MI:0519 | glutathione s tranferase tag | in vitro | Lufei,2007 | support | certain | |
| experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Lufei,2007 | support | certain | InteractionDetection |
| experimental | MI:0005 | alanine scanning | in vivo/in vitro/in silico | Lufei,2007 | support | certain | FeatureDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (Q13526) PIN1_HUMAN | PF00397
(WW)
WW domain |
7 | 37 | [mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000060:
Phosphorylation of S727 in the Pin1-binding motif of Signal transducer and activator of transcription 3 (STAT3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
Pathways
- AGE RAGE signaling pathway in diabetic complications
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Chemical carcinogenesis receptor activation
- Chemokine signaling pathway
- Coronavirus disease COVID 19
- EGFR tyrosine kinase inhibitor resistance
- Epstein Barr virus infection
- FoxO signaling pathway
- Growth hormone synthesis, secretion and action
- HIF 1 signaling pathway
- Hepatitis B
- Hepatitis C
- Human cytomegalovirus infection
- Inflammatory bowel disease
- Insulin resistance
- JAK STAT signaling pathway
- Kaposi sarcoma associated herpesvirus infection
- Lipid and atherosclerosis
- Measles
- MicroRNAs in cancer
- Necroptosis
- Non small cell lung cancer
- PD L1 expression and PD 1 checkpoint pathway in cancer
- Pancreatic cancer
- Pathways in cancer
- Prolactin signaling pathway
- Proteoglycans in cancer
- Signaling pathways regulating pluripotency of stem cells
- Th17 cell differentiation
- Toxoplasmosis
- Viral carcinogenesis
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement