| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI001964 | P35222 CTNNB1 CTNB1_HUMAN |
243 | 248 | GIPALVKMLGSPVDSVLFYA | TP | --- | Homo sapiens (Human) | 781 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0096 | pull down | in vivo/in vitro | support | likely | InteractionDetection | |
| experimental | MI:0519 | glutathione s tranferase tag | in vitro | Ryo,2001 | support | likely | |
| experimental | MI:0434 | phosphatase assay | in vitro | Ryo,2001 | support | likely | InteractionDetection |
| experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Ryo,2001 | support | likely | InteractionDetection |
| experimental | MI:0005 | alanine scanning | in vivo/in vitro/in silico | Ryo,2001 | support | likely | FeatureDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (Q9QUR7) PIN1_MOUSE | PF00397
(WW)
WW domain |
7 | 37 | [mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000056:
Phosphorylation of S246 in the Pin1-binding motif of Catenin beta-1 (CTNNB1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
Pathways
- Adherens junction
- Alzheimer disease
- Arrhythmogenic right ventricular cardiomyopathy
- Bacterial invasion of epithelial cells
- Basal cell carcinoma
- Breast cancer
- Colorectal cancer
- Cushing syndrome
- Endometrial cancer
- Fluid shear stress and atherosclerosis
- Focal adhesion
- Gastric cancer
- Hepatitis C
- Hepatocellular carcinoma
- Hippo signaling pathway
- Human cytomegalovirus infection
- Human papillomavirus infection
- Kaposi sarcoma associated herpesvirus infection
- Leukocyte transendothelial migration
- Melanogenesis
- Pathways in cancer
- Pathways of neurodegeneration multiple diseases
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Salmonella infection
- Signaling pathways regulating pluripotency of stem cells
- Thyroid cancer
- Thyroid hormone signaling pathway
- Wnt signaling pathway
Please cite:
The Eukaryotic Linear Motif resource: 2022 release.
(PMID:34718738)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement