ELM - instance DEG_SCF_SKP2-CKS1_1 in sequence P49918 at position 306

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001939	P49918 CDKN1C CDN1C_HUMAN	306	313	SPSAAPGVGSVEQTPRKRLR	TP	---	Homo sapiens (Human)	316

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0997	ubiquitinase assay	in vitro	Kamura,2003	support	certain	InteractionDetection
experimental	MI:0788	knock out	in vivo	Kamura,2003	support	certain
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Kamura,2003	support	certain	InteractionDetection
experimental	MI:0005	alanine scanning	in vivo/in vitro/in silico	Kamura,2003	support	certain	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000313:

Binding of Cyclin-dependent kinase inhibitor 1C (CDKN1C) (p57) to the SCF-Skp2 ubiquitin ligase complex requires phosphorylation of p57 (CDKN1C) at T310, and association of the F-box protein S-phase kinase-associated protein 2 (SKP2) with the regulatory Cyclin-dependent kinases regulatory subunit 1 (CKS1B). SKP2 and CKS1B together generate a composite binding site for p57 (CDKN1C).

Pathways

KEGG: The sequence P49918 is implicated in the following 1 Pathway: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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