Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
---|---|---|---|---|---|---|---|---|
ELMI001938 | P46527 CDKN1B CDN1B_HUMAN |
183 | 190 | GSPNAGSVEQTPKKPGLRRR | TP |
2AST |
Homo sapiens (Human) | 198 |
Instance evidence
Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
---|---|---|---|---|---|---|---|
experimental | MI:0997 | ubiquitinase assay | in vitro | Hao,2005 | support | certain | InteractionDetection |
experimental | MI:0074 | mutation analysis | in vivo/in vitro | Hao,2005 | support | certain | FeatureDetection |
experimental | MI:0114 | x-ray crystallography | in vitro | Hao,2005 | support | certain | InteractionDetection FeatureDetection |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000312:
Binding of Cyclin-dependent kinase inhibitor 1B (CDKN1B) (p27) to the SCF-Skp2 ubiquitin ligase complex requires phosphorylation of p27 (CDKN1B) at T187, and association of the F-box protein S-phase kinase-associated protein 2 (SKP2) with the regulatory Cyclin-dependent kinases regulatory subunit 1 (CKS1B). SKP2 and CKS1B together generate a composite binding site for p27 (CDKN1B). While some residues, including the phosphorylated T187, bind to CKS1B and others to SKP2, the E185 makes contact with residues of both CKS1B and SKP2.
Pathways
KEGG: The sequence P46527 is implicated in the following 19 Pathways: (color codes: This sequence=red, interacting sequence=orange)- AGE RAGE signaling pathway in diabetic complications
- Cell cycle
- Chronic myeloid leukemia
- Cushing syndrome
- Endocrine resistance
- Epstein Barr virus infection
- ErbB signaling pathway
- FoxO signaling pathway
- Gastric cancer
- HIF 1 signaling pathway
- Human papillomavirus infection
- Measles
- MicroRNAs in cancer
- PI3K Akt signaling pathway
- Pathways in cancer
- Prostate cancer
- Small cell lung cancer
- Transcriptional misregulation in cancer
- Viral carcinogenesis
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement