Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
---|---|---|---|---|---|---|---|---|
ELMI001696 | P23385 Grm1 GRM1_RAT |
1152 | 1156 | EDSPALTPPSPFRDSVASGS | TP | --- | Rattus norvegicus (Norway rat) | 1199 |
Instance evidence
Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
---|---|---|---|---|---|---|---|
experimental | MI:0096 | pull down | in vivo/in vitro | support | certain | InteractionDetection | |
experimental | MI:0519 | glutathione s tranferase tag | in vitro | Beneken,2000 | support | certain | |
predicted | MI:0114 | x-ray crystallography | in vitro | Tu,1998 | support | certain | InteractionDetection FeatureDetection |
experimental | MI:0113 | western blot | in vitro | Beneken,2000 | support | certain | ParticipantIdentification FeatureDetection |
experimental | MI:0074 | mutation analysis | in vivo/in vitro | Beneken,2000 | support | certain | FeatureDetection |
Interactions
Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
---|---|---|---|---|---|
(Q9Z214) HOME1_RAT | PF00568
(WH1)
WH1 domain |
1 | 107 | [mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000496:
Alternative splicing removes the EVH1-binding motif of Metabotropic glutamate receptor 1 (Grm1), abrogating binding to Homer protein homolog 1 (Homer1), which is important for spatial targeting of Grm1.
Pathways
KEGG: The sequence P23385 is implicated in the following 13 Pathways: (color codes: This sequence=red, interacting sequence=orange)- Calcium signaling pathway
- Estrogen signaling pathway
- FoxO signaling pathway
- Gap junction
- Glutamatergic synapse
- Long term depression
- Long term potentiation
- Neuroactive ligand receptor interaction
- Pathways of neurodegeneration multiple diseases
- Phospholipase D signaling pathway
- Retrograde endocannabinoid signaling
- Spinocerebellar ataxia
- Taste transduction
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement