ELM - instance DOC_AGCK_PIF_1 in sequence P11792 at position 733

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001634	P11792 SCH9 SCH9_YEAST	733	738	SPAMQAKFAGFTFVDESAID	TP	---	Saccharomyces cerevisiae S288c	824

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0096	pull down	in vivo/in vitro		support	likely	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Voordeckers,2011	support	likely
experimental	MI:0424	protein kinase assay	in vivo/in vitro	Voordeckers,2011	support	likely	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Voordeckers,2011	support	likely	FeatureDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(Q03407) PKH1_YEAST	PF00069 (Pkinase) Protein kinase domain	125	391		[mitab][xml]

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000150:

Phosphorylation of T737 by Serine/threonine-protein kinase TOR1 (TOR1) in the PIF pocket-binding motif of Serine/threonine-protein kinase SCH9 (SCH9) induces intramolecular binding and kinase cis-activation.

Pathways

KEGG: The sequence P11792 is implicated in the following 2 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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