ELM - instance DOC_AGCK_PIF_1 in sequence P18654 at position 382

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001628	P18654 Rps6ka3 KS6A3_MOUSE	382	387	SANAHQLFRGFSFVAITSDD	TP	---	Mus musculus (House mouse)	740

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0424	protein kinase assay	in vivo/in vitro	Frodin,2000	support	likely	InteractionDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Frodin,2000	support	likely	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Frodin,2000	support	likely	FeatureDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(O15530) PDPK1_HUMAN	PF00069 (Pkinase) Protein kinase domain	82	341		[mitab][xml]

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000151:

Auto-phosphorylation of S386 in the PIF pocket-binding motif of Ribosomal protein S6 kinase alpha-3 (Rps6ka3) induces intramolecular binding and kinase cis-activation.

Pathways

KEGG: The sequence P18654 is implicated in the following 10 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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