Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
---|---|---|---|---|---|---|---|---|
ELMI001598 | P07550 ADRB2 ADRB2_HUMAN |
408 | 413 | VPSDNIDSQGRNCSTNDSLL | TP |
1GQ4 |
Homo sapiens (Human) | 413 |
Instance evidence
Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
---|---|---|---|---|---|---|---|
experimental | MI:0047 | far western blotting | in vitro | Karthikeyan,2002 | support | certain | InteractionDetection |
experimental | MI:0074 | mutation analysis | in vivo/in vitro | Karthikeyan,2002 | support | certain | FeatureDetection |
experimental | MI:0114 | x-ray crystallography | in vitro | Karthikeyan,2002 | support | certain | InteractionDetection FeatureDetection |
Interactions
Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
---|---|---|---|---|---|
(O14745) NHRF1_HUMAN | PF00595
(PDZ)
PDZ domain (Also known as DHR or GLGF) |
[mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000208:
Phosphorylation of S411 in the PDZ-binding motif of Beta-2 adrenergic receptor (ADRB2) by inhibits its interaction with the Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) protein.
Pathways
KEGG: The sequence P07550 is implicated in the following 9 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement