| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI001515 | Q14209 E2F2 E2F2_HUMAN |
420 | 428 | GLEAGEGISDLFDSYDLGDL | TP |
1N4M 
|
Homo sapiens (Human) | 437 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0119 | mutation decreasing interaction | in vivo/in vitro | Liban,2016 | support | certain | InteractionDetection |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Liban,2016 | support | certain | FeatureDetection |
| experimental | MI:0065 | isothermal titration calorimetry | in vitro | Liban,2016 | support | certain | InteractionDetection |
| experimental | MI:0114 | x-ray crystallography | in vitro | Lee,2002 | support | certain | InteractionDetection FeatureDetection |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Lee,2002 | support | certain | FeatureDetection |
| experimental | MI:0065 | isothermal titration calorimetry | in vitro | Lee,2002 | support | certain | InteractionDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (P06400) RB_HUMAN | PF01858
(RB_A)
Retinoblastoma-associated protein A domain |
373 | 573 | 0.06/0.06 | [mitab][xml] |
| (P06400) RB_HUMAN | PF01857
(RB_B)
Retinoblastoma-associated protein B domain |
645 | 766 | [mitab][xml] | |
| (P28749) RBL1_HUMAN | IPR002720
(Retinoblastoma-associated protein A-box)
Retinoblastoma-like and retinoblastoma-associated proteins may have a function in cell cycle regulation |
385 | 578 | 3.1/3.1 | [mitab][xml] |
Pathways
- Bladder cancer
- Breast cancer
- Cell cycle
- Cellular senescence
- Chronic myeloid leukemia
- Cushing syndrome
- Endocrine resistance
- Epstein Barr virus infection
- Gastric cancer
- Glioma
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human T cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Kaposi sarcoma associated herpesvirus infection
- Melanoma
- MicroRNAs in cancer
- Non small cell lung cancer
- Pancreatic cancer
- Pathways in cancer
- Prostate cancer
- Small cell lung cancer
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement