ELM - instance DEG_SCF_FBW7_2 in sequence P03070 at position 699

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001402	P03070 Large T antig LT_SV40	699	705	ICRGFTCFKKPPTPPPEPET	TP	---	Simian virus 40	708

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Welcker,2005	support	certain	InteractionDetection
experimental	MI:0017	classical fluorescence spectroscopy	in vitro	Welcker,2005	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Welcker,2005	support	certain	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000020:

Phosphorylation of T701 in the degron of Large T antigen induces binding to the F-box/WD repeat-containing protein 7 (FBXW7) protein, which recruits it to the SCF ubiquitin ligase complex where it is marked for degradation.

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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