The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
LIG_BIR_III_2

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI001318 P55211 CASP9
CASP9_HUMAN 		315 319 PGSNPEPDATPFQEGLRTFD TP 1NW9  
pdb:1NW9 3D9T  
pdb:3D9T 		Homo sapiens (Human) 416

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0074 mutation analysis in vivo/in vitro Shiozaki,2003 support certain FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Shiozaki,2003 support certain InteractionDetection FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Kulathila,2009 support certain InteractionDetection FeatureDetection
experimental MI:0107 surface plasmon resonance in vitro Kulathila,2009 support certain InteractionDetection FeatureDetection

o  Switches



This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:
  • SWTI000527:
    ELM Switch SWTI000527
    Binding of the BIR domain-binding motif of Caspase-9 (CASP9) to the BIR domains of Baculoviral IAP repeat-containing protein 4 (XIAP) requires cleavage of Caspase-9 (CASP9) at D315, since this results in a functional neo N-terminal motif. BIR domains are found in Inhibitor of Apoptosis Proteins (IAPs) that suppress the activity of activated caspases, either by directly inhibiting caspase catalytic activity, or by targeting caspases for degradation by ubiquitin modification.
  • SWTI000528:
    ELM Switch SWTI000528
    Binding of the BIR domain-binding motif of Caspase-9 (CASP9) to the BIR domains of Baculoviral IAP repeat-containing protein 2 (BIRC2) requires cleavage of Caspase-9 (CASP9) at D315, since this results in a functional neo N-terminal motif. BIR domains are found in Inhibitor of Apoptosis Proteins (IAPs) that suppress the activity of activated caspases, either by directly inhibiting caspase catalytic activity, or by targeting caspases for degradation by ubiquitin modification.

o  Pathways

KEGG: The sequence P55211 is implicated in the following 35 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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