ELM - instance DEG_SCF_TRCP1_1 in sequence Q12959 at position 597

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001310	Q12959 DLG1 DLG1_HUMAN	597	602	FDYDKTKDSGLPSQGLNFKF	TP	---	Homo sapiens (Human)	904

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0096	pull down	in vivo/in vitro		support	likely	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Mantovani,2003	support	likely
experimental	MI:0113	western blot	in vitro	Mantovani,2003	support	likely	ParticipantIdentification FeatureDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Mantovani,2003	support	likely	InteractionDetection
experimental	MI:0256	rna interference	in vivo	Mantovani,2003	support	likely	InteractionDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000164:

Dual phosphorylation of S598 and S602 in the TrCP1-binding motif of Disks large homolog 1 (DLG1) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.

Pathways

KEGG: The sequence Q12959 is implicated in the following 6 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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