| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI001309 | P18848 ATF4 ATF4_HUMAN |
218 | 224 | DTPSDNDSGICMSPESYLGS | TP | --- | Homo sapiens (Human) | 351 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0018 | two hybrid | in vivo | Lassot,2001 | support | certain | InteractionDetection |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Lassot,2001 | support | certain | FeatureDetection |
| experimental | MI:0517 | radiolabel | in vitro | Lassot,2001 | support | certain | |
| experimental | MI:0424 | protein kinase assay | in vivo | Lassot,2001 | support | certain | InteractionDetection |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000161:
Dual phosphorylation of S219 and S224 in the TrCP1-binding motif of Cyclic AMP-dependent transcription factor ATF-4 (ATF4) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.
Pathways
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Aldosterone synthesis and secretion
- Alzheimer disease
- Amphetamine addiction
- Amyotrophic lateral sclerosis
- Apoptosis
- Chemical carcinogenesis receptor activation
- Cholinergic synapse
- Cocaine addiction
- Cortisol synthesis and secretion
- Cushing syndrome
- Dopaminergic synapse
- Estrogen signaling pathway
- Glucagon signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human T cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Insulin secretion
- Lipid and atherosclerosis
- Long term potentiation
- Longevity regulating pathway
- MAPK signaling pathway
- Mitophagy animal
- Neurotrophin signaling pathway
- Non alcoholic fatty liver disease
- PI3K Akt signaling pathway
- Parathyroid hormone synthesis, secretion and action
- Parkinson disease
- Pathways of neurodegeneration multiple diseases
- Prion disease
- Prostate cancer
- Protein processing in endoplasmic reticulum
- Relaxin signaling pathway
- TNF signaling pathway
- Thyroid hormone synthesis
- Viral carcinogenesis
- cGMP PKG signaling pathway
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement