ELM - instance DEG_SCF_TRCP1_1 in sequence Q53EL6 at position 70

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001307	Q53EL6 PDCD4 PDCD4_HUMAN	70	76	RKNSSRDSGRGDSVSDSGSD	TP	---	Homo sapiens (Human)	469

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0074	mutation analysis	in vivo/in vitro	Dorrello,2006	support	likely	FeatureDetection
experimental	MI:0424	protein kinase assay	in vivo	Dorrello,2006	support	likely	InteractionDetection
experimental	MI:0943	detection by mass spectrometry	in vivo/in vitro	Dorrello,2006	support	likely	InteractionDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000166:

Dual phosphorylation of S71 and S76 in the TrCP1-binding motif of Programmed cell death protein 4 (PDCD4) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.

Pathways

KEGG: The sequence Q53EL6 is implicated in the following 2 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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