| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI001220 | Q16665 HIF1A HIF1A_HUMAN |
562 | 574 | LEMLAPYIPMDDDFQLRSFD | TP |
1LM8 
1LQB 
|
Homo sapiens (Human) | 826 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0114 | x-ray crystallography | in vitro | Hon,2002 | support | certain | InteractionDetection FeatureDetection |
| experimental | MI:0065 | isothermal titration calorimetry | in vitro | Min,2002 | support | certain | InteractionDetection |
| experimental | MI:0107 | surface plasmon resonance | in vitro | Hon,2002 | support | certain | InteractionDetection FeatureDetection |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000023:
Hydroxylation of P564 in the VHL-binding motif of Hypoxia-inducible factor 1-alpha (HIF1A) induces binding to the Von Hippel-Lindau disease tumor suppressor (VHL) protein.
Pathways
- Autophagy animal
- Central carbon metabolism in cancer
- Chemical carcinogenesis reactive oxygen species
- Choline metabolism in cancer
- HIF 1 signaling pathway
- Kaposi sarcoma associated herpesvirus infection
- Mitophagy animal
- PD L1 expression and PD 1 checkpoint pathway in cancer
- Pathways in cancer
- Proteoglycans in cancer
- Renal cell carcinoma
- Th17 cell differentiation
- Thyroid hormone signaling pathway
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement