ELM - instance LIG_CORNRBOX in sequence Q9Y618 at position 2350

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI000750	Q9Y618 NCOR2 NCOR2_HUMAN	2350	2358	STNMGLEAIIRKALMGKYDQ	TP	1KKQ	Homo sapiens (Human)	2525

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0074	mutation analysis	in vivo/in vitro	Xu,2002	support	certain	FeatureDetection
experimental	MI:0114	x-ray crystallography	in vitro	Xu,2002	support	certain	InteractionDetection FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000249:

Binding of the 28666" target="_blank">leukotriene D4 ligand to the nuclear Peroxisome proliferator-activated receptor alpha (PPARA) makes the binding site for the CORNRBOX motif of Nuclear receptor corepressor 2 (NCOR2) inaccessible.

Pathways

KEGG: The sequence Q9Y618 is implicated in the following 2 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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