ELM - instance LIG_Dynein_DLC8_1 in sequence O43521 at position 110

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI000264	O43521 BCL2L11 B2L11_HUMAN	110	116	SPAPMSCDKSTQTPSPPCQA	TP	1F95	Homo sapiens (Human)	198

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0096	pull down	in vivo/in vitro		support	certain	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Lo,2001	support	certain
experimental	MI:0077	nuclear magnetic resonance	in vitro	Fan,2001	support	certain	InteractionDetection FeatureDetection
experimental	MI:0018	two hybrid	in vivo	Lo,2001	support	certain	InteractionDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000494:

Alternative splicing removes the Dynein-binding motif of Bcl-2-like protein 11 (BCL2L11), abrogating binding to Dynein light chain 1, cytoplasmic (DYNLL1). Most BCL2L11 in healthy cells is sequestered away bound to DYNLL1 (the exception is Bim-S Isoform BCL2-like 11 transcript variant 9). Cells exposed to environmental stress up-regulate c-Jun NH(2)-terminal kinases (JNK) that phosphorylate both BCL2L11 and BMF, releasing them from motor complexes and promoting apoptosis.

Pathways

KEGG: The sequence O43521 is implicated in the following 10 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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