| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length | 
|---|---|---|---|---|---|---|---|---|
| ELMI000027 |  P51617 IRAK1 IRAK1_HUMAN  | 
        540 | 548 | ASCIPPSPQENSYVSSTGRA | TP | --- | Homo sapiens (Human) | 712 | 
  Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes | 
|---|---|---|---|---|---|---|---|
| experimental | MI:0065 | isothermal titration calorimetry | in vitro | Ye,2002 | support | certain | InteractionDetection | 
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Ye,2002 | support | certain | FeatureDetection | 
  Interactions 
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes | 
|---|---|---|---|---|---|
| (Q9Y4K3) TRAF6_HUMAN |  IPR037309
                  (TNF receptor-associated factor 6, MATH domain) 
                  TNF receptor-associated factor 6 (TRAF6) regulates a diverse array of processes, including adaptive immunity, innate immunity, bone metabolism and tissue development  | 
             351 | 500 | 518.1/518.1 | [mitab][xml] | 
  Pathways 
- Chagas disease
 - Coronavirus disease COVID 19
 - Epstein Barr virus infection
 - Hepatitis B
 - Herpes simplex virus 1 infection
 - Human immunodeficiency virus 1 infection
 - Leishmaniasis
 - Lipid and atherosclerosis
 - MAPK signaling pathway
 - Measles
 - NF kappa B signaling pathway
 - Neurotrophin signaling pathway
 - Pathogenic Escherichia coli infection
 - Pertussis
 - Salmonella infection
 - Toll like receptor signaling pathway
 - Toxoplasmosis
 - Tuberculosis
 - Yersinia infection
 
    
        Please cite: 
            ELM-the Eukaryotic Linear Motif resource-2024 update.
        
    (PMID:37962385)
    
    
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
