The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

Pathways linked from ELM instances

The following list contains those pathways annotated at the "Kyoto Encyclopedia of Genes and Genomes" (KEGG) database for which at least one sequence is stored in the ELM database (containing at least one ELM instance). Sequences have been mapped from Uniprot to KEGG and colored in the pathway according to a simple colorscheme.

TaxonPathway entryPathway name# Instances# Sequences
rno05221 Acute myeloid leukemia 4 4
rno04520 Adherens junction 2 2
rno04920 Adipocytokine signaling pathway 4 1
rno04261 Adrenergic signaling in cardiomyocytes 4 4
rno05143 African trypanosomiasis 1 1
rno04933 AGE RAGE signaling pathway in diabetic complications 1 1
rno05034 Alcoholism 2 2
rno04960 Aldosterone regulated sodium reabsorption 6 3
rno04925 Aldosterone synthesis and secretion 2 2
rno05010 Alzheimer disease 10 6
rno05031 Amphetamine addiction 3 3
rno04152 AMPK signaling pathway 7 4
rno05014 Amyotrophic lateral sclerosis 3 3
rno04612 Antigen processing and presentation 1 1
rno04371 Apelin signaling pathway 4 4
rno04210 Apoptosis 2 2
rno05310 Asthma 1 1
rno04140 Autophagy animal 7 4
rno04360 Axon guidance 4 4
rno05100 Bacterial invasion of epithelial cells 6 5
rno05217 Basal cell carcinoma 1 1
rno04662 B cell receptor signaling pathway 2 2
rno04976 Bile secretion 2 2
rno05219 Bladder cancer 2 2
rno05224 Breast cancer 3 3
rno04020 Calcium signaling pathway 5 4
rno04024 cAMP signaling pathway 8 8
rno04973 Carbohydrate digestion and absorption 1 1
rno04260 Cardiac muscle contraction 1 1
rno04514 Cell adhesion molecules 1 1
rno04218 Cellular senescence 2 2
rno05230 Central carbon metabolism in cancer 1 1
rno04022 cGMP PKG signaling pathway 8 5
rno05142 Chagas disease 1 1
rno05208 Chemical carcinogenesis reactive oxygen species 3 3
rno05207 Chemical carcinogenesis receptor activation 6 6
rno04062 Chemokine signaling pathway 9 8
rno04979 Cholesterol metabolism 1 1
rno05231 Choline metabolism in cancer 3 3
rno04725 Cholinergic synapse 3 3
rno05220 Chronic myeloid leukemia 2 2
rno04713 Circadian entrainment 3 3
rno05030 Cocaine addiction 2 2
rno05210 Colorectal cancer 5 5
rno04927 Cortisol synthesis and secretion 1 1
rno04625 C type lectin receptor signaling pathway 2 2
rno04934 Cushing syndrome 3 3
rno05415 Diabetic cardiomyopathy 4 1
rno05414 Dilated cardiomyopathy 1 1
rno04728 Dopaminergic synapse 4 4
rno04512 ECM receptor interaction 1 1
rno01521 EGFR tyrosine kinase inhibitor resistance 6 6
rno04961 Endocrine and other factor regulated calcium reabsorption 3 3
rno01522 Endocrine resistance 5 5
rno04144 Endocytosis 14 10
rno05213 Endometrial cancer 3 3
rno05169 Epstein Barr virus infection 2 2
rno04012 ErbB signaling pathway 7 7
rno04915 Estrogen signaling pathway 5 5
rno04664 Fc epsilon RI signaling pathway 3 3
rno04666 Fc gamma R mediated phagocytosis 7 6
rno05418 Fluid shear stress and atherosclerosis 1 1
rno04510 Focal adhesion 8 7
rno04068 FoxO signaling pathway 6 3
rno04727 GABAergic synapse 3 3
rno04540 Gap junction 6 5
rno04971 Gastric acid secretion 3 3
rno05226 Gastric cancer 3 3
rno05214 Glioma 1 1
rno04724 Glutamatergic synapse 12 10
rno04929 GnRH secretion 2 2
rno04912 GnRH signaling pathway 4 4
rno04935 Growth hormone synthesis, secretion and action 9 5
rno04340 Hedgehog signaling pathway 1 1
rno04640 Hematopoietic cell lineage 1 1
rno05161 Hepatitis B 3 3
rno05160 Hepatitis C 2 2
rno05225 Hepatocellular carcinoma 4 4
rno05168 Herpes simplex virus 1 infection 4 4
rno04066 HIF 1 signaling pathway 3 3
rno04390 Hippo signaling pathway 1 1
rno04392 Hippo signaling pathway multiple species 1 1
rno05163 Human cytomegalovirus infection 7 6
rno05170 Human immunodeficiency virus 1 infection 5 5
rno05165 Human papillomavirus infection 7 7
rno05166 Human T cell leukemia virus 1 infection 3 3
rno05016 Huntington disease 4 3
rno04750 Inflammatory mediator regulation of TRP channels 2 2
rno05164 Influenza A 1 1
rno00562 Inositol phosphate metabolism 2 2
rno04931 Insulin resistance 6 3
rno04911 Insulin secretion 2 2
rno04910 Insulin signaling pathway 8 5
rno05167 Kaposi sarcoma associated herpesvirus infection 3 3
rno05134 Legionellosis 1 1
rno04670 Leukocyte transendothelial migration 3 2
rno05417 Lipid and atherosclerosis 5 5
rno04211 Longevity regulating pathway 7 4
rno04213 Longevity regulating pathway multiple species 7 4
rno04730 Long term depression 5 5
rno04720 Long term potentiation 8 7
rno04010 MAPK signaling pathway 5 5
rno05162 Measles 3 3
rno04916 Melanogenesis 2 2
rno05218 Melanoma 2 2
rno01100 Metabolic pathways 4 4
rno05206 MicroRNAs in cancer 6 3
rno04978 Mineral absorption 1 1
rno04137 Mitophagy animal 1 1
rno05032 Morphine addiction 1 1
rno04150 mTOR signaling pathway 7 4
rno04650 Natural killer cell mediated cytotoxicity 2 2
rno04217 Necroptosis 1 1
rno04080 Neuroactive ligand receptor interaction 8 7
rno04722 Neurotrophin signaling pathway 7 4
rno04613 Neutrophil extracellular trap formation 2 2
rno04064 NF kappa B signaling pathway 3 2
rno05033 Nicotine addiction 4 4
rno04621 NOD like receptor signaling pathway 1 1
rno04932 Non alcoholic fatty liver disease 6 3
rno05223 Non small cell lung cancer 2 2
rno04330 Notch signaling pathway 1 1
rno04114 Oocyte meiosis 2 2
rno04380 Osteoclast differentiation 1 1
rno04913 Ovarian steroidogenesis 1 1
rno04921 Oxytocin signaling pathway 4 4
rno05212 Pancreatic cancer 4 4
rno04972 Pancreatic secretion 2 2
rno04928 Parathyroid hormone synthesis, secretion and action 2 2
rno05012 Parkinson disease 1 1
rno05200 Pathways in cancer 7 7
rno05022 Pathways of neurodegeneration multiple diseases 9 8
rno05235 PD L1 expression and PD 1 checkpoint pathway in cancer 3 3
rno04070 Phosphatidylinositol signaling system 2 2
rno04072 Phospholipase D signaling pathway 8 7
rno04151 PI3K Akt signaling pathway 10 7
rno04611 Platelet activation 3 3
rno01524 Platinum drug resistance 1 1
rno05340 Primary immunodeficiency 1 1
rno05020 Prion disease 2 2
rno04914 Progesterone mediated oocyte maturation 2 2
rno04917 Prolactin signaling pathway 2 2
rno05215 Prostate cancer 2 2
rno04974 Protein digestion and absorption 1 1
rno04141 Protein processing in endoplasmic reticulum 1 1
rno05205 Proteoglycans in cancer 7 7
rno04964 Proximal tubule bicarbonate reclamation 1 1
rno00230 Purine metabolism 1 1
rno04015 Rap1 signaling pathway 6 5
rno04014 Ras signaling pathway 4 4
rno04810 Regulation of actin cytoskeleton 7 6
rno04923 Regulation of lipolysis in adipocytes 5 2
rno04926 Relaxin signaling pathway 3 3
rno05211 Renal cell carcinoma 4 4
rno04614 Renin angiotensin system 1 1
rno04723 Retrograde endocannabinoid signaling 9 8
rno04970 Salivary secretion 2 2
rno05132 Salmonella infection 3 3
rno04726 Serotonergic synapse 3 3
rno04550 Signaling pathways regulating pluripotency of stem cells 2 2
rno00600 Sphingolipid metabolism 1 1
rno04071 Sphingolipid signaling pathway 3 3
rno05017 Spinocerebellar ataxia 3 3
rno03040 Spliceosome 1 1
rno04721 Synaptic vesicle cycle 7 7
rno04742 Taste transduction 4 4
rno04660 T cell receptor signaling pathway 4 4
rno04350 TGF beta signaling pathway 1 1
rno04659 Th17 cell differentiation 1 1
rno04658 Th1 and Th2 cell differentiation 1 1
rno04714 Thermogenesis 2 2
rno05216 Thyroid cancer 1 1
rno04919 Thyroid hormone signaling pathway 4 4
rno04918 Thyroid hormone synthesis 3 3
rno04530 Tight junction 2 2
rno04668 TNF signaling pathway 2 2
rno04620 Toll like receptor signaling pathway 2 2
rno05145 Toxoplasmosis 2 2
rno05152 Tuberculosis 2 2
rno04930 Type II diabetes mellitus 4 1
rno04270 Vascular smooth muscle contraction 2 2
rno04370 VEGF signaling pathway 4 4
rno05203 Viral carcinogenesis 4 4
rno04310 Wnt signaling pathway 1 1
rno05135 Yersinia infection 7 6
Links redirect to the KEGG database with a color overlay corresponding to ELM classes.

Coloring is as follows:
CLV (cleavage site)
DOC (docking site)
DEG (degradation motif)
LIG (ligand binding motif)
MOD (modification site)
TRG (targeting motif)
multiple classes per sequence
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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