The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

Currently 15 instance candidates need annotation:

Id Identifier Sequence References Position Logic Notes Status
32 DOC_CYCLIN_1 CDN1A_HUMAN 15964852 155-159 true positive this instance is annotated as TN, but probably should be TP. first draft
31 DEG_SCF_FBW7_2 CCNE1_HUMAN Hao,2007 74-81 true positive c-terminal FBW7-binding degron required to bind FBW7 (no itc signal for peptide containing only the n-terminal degron) first draft
30 LIG_14-3-3_3 CDN1B_HUMAN 12042314;14504289 193-198 true positive Instance does not match regular expression
See also http://switches.elm.eu.org/switch.php?switch=SWTI000693
first draft
29 LIG_14-3-3_3 CDN1B_HUMAN 15057270 154-159 true positive Instance does not match regular expression
See also http://switches.elm.eu.org/switch.php?switch=SWTI000692
first draft
28 LIG_SH2_SRC DAB1_MOUSE Keshvara,2001;Gao,2012 185-188 true positive LIG_SH2_SRC motif does not allow 'T' in position 2. Should be updated.
See also http://switches.elm.eu.org/switch.php?switch=SWTI000619
first draft
22 LIG_FHA_1 P64897 Nott,2009 20-26 true positive The sequence does not fit the regular expression ..(T)..[ILV]. defined in ELM, however would fit ..(T)..[ILVF]. first draft
20 CLV_C14_Caspase3-7 P31809 12637508 457-461 true positive The sequence does not fit the regular expression [DSTE][^P][^DEWHFYC]D[GSAN] defined in ELM, however would fit [DSTE][^P][^DEWHFYC]D[GSANL]; see 109479712 first draft
19 LIG_FHA_2 P18887 Ali,2009 517-523 true positive The sequence does not fit the regular expression ..(T)..[DE]. defined in ELM, however would fit ..(T)..[DEN]. first draft
14 TRG_LysEnd_APsAcLL_1 MCLN1_HUMAN 16497227 573-578 true positive first draft
13 LIG_MAPK_1 P52564 10716930 7-15 true positive from Figure 1 in 14616089 first draft
12 LIG_MAPK_1 P46734 10716930 20-27 true positive from Figure 1 in 14616089 first draft
21 TRG_ER_diArg_1 Q9P0K1 Godde,2006 828-831 true positive The sequence does not fit the regular expression ([LIVMFYWPR]R[^YFWDE]{0, 1}R)|(R[^YFWDE]{0, 1}R[LIVMFYWPR]) defined in ELM, however would fit ([GLIVMFYWPR]R[^YFWDE]{0, 1}R)|(R[^YFWDE]{0, 1}R[LIVMFYWPR]) or ([LIVMFYWPR]R[^YFWDE]{0, 1}R)|(R[^YFWDE]{0, 1}R[LIVMFYWPRS]); however, the instance needs more detailed experimental evidence to be validated. deleted
23 LIG_Dynein_DLC8 Q9Y4I1 17029413;16981716 1284-1290 true positive The sequence does not fit the regular expression [^P].[KR].TQT defined in ELM. It has a M at the position of the invariant Q. As more similar instances accumulate, the RE might be redefined, or a different subclass of dynein-binding motifs might be defined. deleted
24 LIG_EVH1_1 XRN1 23142987 1338-1342 true positive deleted
25 DOC_USP7_1 MDM4_HUMAN unknown 140-144 not specified deleted
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

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