ELM - instance TRG_NLS_MonoExtN_4 in sequence P09959 at position 161

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002196	P09959 SWI6 SWI6_YEAST	161	167	HRELGSPLKKLKIDTSVIDA	TP	---	Saccharomyces cerevisiae S288c	803

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0416	fluorescence microscopy		Sidorova,1996	support	certain	InteractionDetection
experimental	MI:0367	green fluorescent protein tag	in vivo	Sidorova,1996	support	certain
experimental	MI:0074	mutation analysis	in vivo/in vitro	Sidorova,1996	support	certain	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000183:

Phosphorylation of S160 adjacent to the NLS of Regulatory protein SWI6 (SWI6) decreases nuclear import of this protein by decreasing the affinity for Importin subunit alpha (SRP1).

Pathways

KEGG: The sequence P09959 is implicated in the following 3 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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