ELM - instance TRG_NLS_MonoExtC_3 in sequence P07270 at position 156

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002163	P07270 PHO4 PHO4_YEAST	156	161	SNSSPYLNKRRGKPGPDSAT	TP	---	Saccharomyces cerevisiae S288c	312

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Kaffman,1998	support	certain	InteractionDetection
experimental	MI:0113	western blot	in vitro	Kaffman,1998	support	certain	ParticipantIdentification FeatureDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Kaffman,1998	support	certain	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000184:

Phosphorylation of S152 adjacent to the NLS of Phosphate system positive regulatory protein PHO4 (PHO4) by the Pho80-Pho85 CDK-Cyclin complex inhibits nuclear import this protein by blocking its interaction with Importin subunit beta-3 (PSE1). Upon phosphate starvation, Pho81 inhibits the Pho80-Pho85 complex, leading to translocation of Phosphate system positive regulatory protein PHO4 (PHO4) to the nucleus, where it regulates expression of phosphate-responsive genes.

Pathways

KEGG: The sequence P07270 is implicated in the following 1 Pathway: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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