ELM - instance TRG_NLS_MonoCore_2 in sequence Q969H0 at position 10

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002452	Q969H0 FBXW7 FBXW7_HUMAN	10	15	QELLSVGSKRRRTGGSLRGN	TP	---	Homo sapiens (Human)	707

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0416	fluorescence microscopy		Welcker,2004	support	likely	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Welcker,2004	support	likely	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000543:

Alternative splicing removes the nuclear localisation signal (NLS) of F-box/WD repeat-containing protein 7 (FBXW7), abrogating binding to Importin subunit alpha-1 (KPNA1). There are two other NLS motifs in the protein, meaning the isoform can still enter the nucleus.

Pathways

KEGG: The sequence Q969H0 is implicated in the following 1 Pathway: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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