ELM - instance TRG_NES_CRM1_1 in sequence O60716 at position 942

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI000915	O60716 CTNND1 CTND1_HUMAN	942	956	GQESLEEELDVLVLDDEGGQ	TP	---	Homo sapiens (Human)	968

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0074	mutation analysis	in vivo/in vitro	van Hengel,1999	support	certain	FeatureDetection
experimental	MI:0405	competition binding	in vitro	van Hengel,1999	support	certain	InteractionDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000609:

Alternative splicing removes the nuclear export signal (NES) of Catenin delta-1 (CTNND1), abrogating binding to Exportin-1 (XPO1). Despite demonstration of the importance of the NES for removing Catenin delta-1 (CTNND1) from the nucleus, those isoforms without NES are rarely found in the nucleus.

Pathways

KEGG: The sequence O60716 is implicated in the following 3 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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