ELM - instance TRG_ER_diLys_1 in sequence P78381 at position 392

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002596	P78381 SLC35A2 S35A2_HUMAN	392	396	RGDLITEPFLPKLLTKVKGS	TP	---	Homo sapiens (Human)	396

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0416	fluorescence microscopy		Kabuss,2005	support	likely	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Kabuss,2005	support	likely	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000522:

Alternative splicing removes the di-lysine ER-retention motif of UDP-galactose translocator (SLC35A2), abrogating binding to Coatomer subunit alpha (COPA). This motif localises Isoform UGT1 exclusively in the Golgi whereas Isoform UGT2 shows dual expression in both the Golgi and the ER. This motif is considered a weak retention signal.

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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