ELM - instance TRG_ER_diArg_1 in sequence Q9UBS5 at position 923

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002074	Q9UBS5 GABBR1 GABR1_HUMAN	923	926	QLQSRQQLRSRRHPPTPPEP	TP	---	Homo sapiens (Human)	961

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0051	fluorescence technology		Margeta-Mitrovic,2000	support	likely	InteractionDetection
experimental	MI:0403	colocalization	in vitro	Margeta-Mitrovic,2000	support	likely
experimental	MI:0074	mutation analysis	in vivo/in vitro	Margeta-Mitrovic,2000	support	likely	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000321:

Interaction of the GABA receptor R2 subunit (Gamma-aminobutyric acid type B receptor subunit 2 (GABBR2)) with the R1 subunit (Gamma-aminobutyric acid type B receptor subunit 1 (GABBR1)) via coiled-coil forming domains masks the ER retention motif in the R1 subunit (Gamma-aminobutyric acid type B receptor subunit 1 (GABBR1)), thereby promoting surface expression of fully assembled GABA receptors.

Pathways

KEGG: The sequence Q9UBS5 is implicated in the following 7 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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