Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
---|---|---|---|---|---|---|---|---|
ELMI002064 | Q05586 GRIN1 NMDZ1_HUMAN |
893 | 895 | STLASSFKRRRSSKDTSTGG | TP | --- | Homo sapiens (Human) | 938 |
Instance evidence
Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
---|---|---|---|---|---|---|---|
experimental | MI:0101 | sequence based prediction | in silico | Scott,2001 | support | certain | InteractionDetection |
experimental | MI:0573 | mutation disrupting interaction | in vivo/in vitro | Scott,2001 | support | certain | |
experimental | MI:0663 | confocal microscopy | in vivo/in vitro | Scott,2001 | support | certain | InteractionDetection |
experimental | MI:0403 | colocalization | in vitro | Scott,2001 | support | certain | |
experimental | MI:0074 | mutation analysis | in vivo/in vitro | Scott,2001 | support | certain | FeatureDetection |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000195:
Phosphorylation of S896 adjacent to the ER retention motif of Glutamate [NMDA] receptor subunit zeta-1 (GRIN1) by PKC subfamily (and possibly S897 by PKA) inactivates the motif and promotes delivery of the receptor to the plasma membrane. Optimal trafficking upon dual phosphorylation of S896 and S897 allows regulation of receptor trafficking by coordinated PKA and PKC signaling.
Pathways
KEGG: The sequence Q05586 is implicated in the following 18 Pathways: (color codes: This sequence=red, interacting sequence=orange)- Alcoholism
- Alzheimer disease
- Amphetamine addiction
- Amyotrophic lateral sclerosis
- Calcium signaling pathway
- Circadian entrainment
- Cocaine addiction
- Glutamatergic synapse
- Huntington disease
- Long term potentiation
- Neuroactive ligand receptor interaction
- Nicotine addiction
- Pathways of neurodegeneration multiple diseases
- Prion disease
- Rap1 signaling pathway
- Ras signaling pathway
- Spinocerebellar ataxia
- cAMP signaling pathway
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement