Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
---|---|---|---|---|---|---|---|---|
ELMI002072 | P04233 CD74 HG2A_HUMAN |
3 | 5 | MHRRRSRSCREDQKPVMDDQ | TP | --- | Homo sapiens (Human) | 296 |
Instance evidence
Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
---|---|---|---|---|---|---|---|
experimental | MI:0051 | fluorescence technology | Schutze,1994 | support | likely | InteractionDetection | |
experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Schutze,1994 | support | likely | InteractionDetection |
experimental | MI:0403 | colocalization | in vitro | Schutze,1994 | support | likely | |
experimental | MI:0074 | mutation analysis | in vivo/in vitro | Schutze,1994 | support | likely | FeatureDetection |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000320:
The basic ER retention motif of HLA class II histocompatibility antigen gamma chain (CD74) is blocked from binding to Coatomer subunit beta (COPB1) by phosphorylation-induced binding of 14-3-3 protein beta/alpha (YWHAB), regulating its release from the ER and trafficking to the plasma membrane.
Pathways
KEGG: The sequence P04233 is implicated in the following 3 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement