Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
---|---|---|---|---|---|---|---|---|
ELMI001207 | P49407 ARRB1 ARRB1_HUMAN |
385 | 395 | TNDDDIVFEDFARQRLKGMK | TP |
2IV8 |
Homo sapiens (Human) | 418 |
Instance evidence
Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
---|---|---|---|---|---|---|---|
experimental | MI:0096 | pull down | in vivo/in vitro | support | certain | InteractionDetection | |
experimental | MI:0519 | glutathione s tranferase tag | in vitro | Edeling,2006 | support | certain | |
experimental | MI:0065 | isothermal titration calorimetry | in vitro | Edeling,2006 | support | certain | InteractionDetection |
experimental | MI:0074 | mutation analysis | in vivo/in vitro | Edeling,2006 | support | certain | FeatureDetection |
experimental | MI:0018 | two hybrid | in vivo | Edeling,2006 | support | certain | InteractionDetection |
experimental | MI:0114 | x-ray crystallography | in vitro | Schmid,2006 | support | certain | InteractionDetection FeatureDetection |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000216:
Binding of Beta-arrestin-1 (ARRB1) to ligand-induced, phosphorylated GPCRs results in a conformational change that makes the AP2-beta interaction motif in Beta-arrestin-1 (ARRB1) accessible for binding to AP-2 complex subunit beta (AP2B1), which mediates internalization of the GPCR.
Pathways
KEGG: The sequence P49407 is implicated in the following 11 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite:
The Eukaryotic Linear Motif resource: 2022 release.
(PMID:34718738)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement