ELM - instance TRG_AP2beta_CARGO_1 in sequence P49407 at position 385

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001207	P49407 ARRB1 ARRB1_HUMAN	385	395	TNDDDIVFEDFARQRLKGMK	TP	2IV8	Homo sapiens (Human)	418

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0096	pull down	in vivo/in vitro		support	certain	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Edeling,2006	support	certain
experimental	MI:0065	isothermal titration calorimetry	in vitro	Edeling,2006	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Edeling,2006	support	certain	FeatureDetection
experimental	MI:0018	two hybrid	in vivo	Edeling,2006	support	certain	InteractionDetection
experimental	MI:0114	x-ray crystallography	in vitro	Schmid,2006	support	certain	InteractionDetection FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000216:

Binding of Beta-arrestin-1 (ARRB1) to ligand-induced, phosphorylated GPCRs results in a conformational change that makes the AP2-beta interaction motif in Beta-arrestin-1 (ARRB1) accessible for binding to AP-2 complex subunit beta (AP2B1), which mediates internalization of the GPCR.

Pathways

KEGG: The sequence P49407 is implicated in the following 11 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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