| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI002553 | P04049 RAF1 RAF1_HUMAN |
254 | 262 | GSLSQRQRSTSTPNVHMVST | TP | --- | Homo sapiens (Human) | 648 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0424 | protein kinase assay | in vitro | Wang,2008 | support | likely | InteractionDetection |
| experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Wang,2008 | support | likely | InteractionDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (P31749) AKT1_HUMAN | PF00069
(Pkinase)
Protein kinase domain |
150 | 408 | [mitab][xml] |
Pathways
- Acute myeloid leukemia
- Alcoholism
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy animal
- Axon guidance
- B cell receptor signaling pathway
- Bladder cancer
- Breast cancer
- C type lectin receptor signaling pathway
- Cellular senescence
- Central carbon metabolism in cancer
- Chemical carcinogenesis reactive oxygen species
- Chemical carcinogenesis receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Chronic myeloid leukemia
- Colorectal cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R mediated phagocytosis
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Influenza A
- Insulin signaling pathway
- JAK STAT signaling pathway
- Kaposi sarcoma associated herpesvirus infection
- Long term depression
- Long term potentiation
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- MicroRNAs in cancer
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non small cell lung cancer
- Oxytocin signaling pathway
- PD L1 expression and PD 1 checkpoint pathway in cancer
- PI3K Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration multiple diseases
- Phospholipase D signaling pathway
- Progesterone mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Renal cell carcinoma
- Salmonella infection
- Serotonergic synapse
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- Thyroid hormone signaling pathway
- Tuberculosis
- VEGF signaling pathway
- Vascular smooth muscle contraction
- cAMP signaling pathway
- cGMP PKG signaling pathway
- mTOR signaling pathway
Diseases
- Sequence Variation VAR_037811 (Pos 260) has been implicated in Noonan Syndrome 5; Ns5 (OMIM:611553).
- Sequence Variation VAR_037813 (Pos 261) has been implicated in Noonan Syndrome 5; Ns5 (OMIM:611553).
- Sequence Variation VAR_037812 (Pos 261) has been implicated in Noonan Syndrome 5; Ns5 (OMIM:611553).
- Sequence Variation VAR_037814 (Pos 261) has been implicated in Noonan Syndrome 5; Ns5 (OMIM:611553).
- Sequence Variation VAR_037807 (Pos 256) has been implicated in Noonan Syndrome 5; Ns5 (OMIM:611553).
- Sequence Variation VAR_037808 (Pos 257) has been implicated in Leopard Syndrome 2; Lprd2 (OMIM:611554).
- Sequence Variation VAR_037809 (Pos 259) has been implicated in Noonan Syndrome 5; Ns5 (OMIM:611553).
Please cite:
The Eukaryotic Linear Motif resource: 2022 release.
(PMID:34718738)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement