ELM - instance MOD_LATS_1 in sequence P46937-2 at position 376

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002406	P46937-2 YAP1 YAP1_HUMAN	376	382	LNSGTYHSRDESTDSGLSMS	TP	---	Homo sapiens (Human)	488

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0403	colocalization	in vitro	Zhao,2007	support	certain
experimental	MI:0434	phosphatase assay	in vitro	Zhao,2007	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Zhao,2007	support	certain	FeatureDetection
experimental	MI:0113	western blot	in vitro	Zhao,2007	support	certain	ParticipantIdentification FeatureDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(Q9NRM7) LATS2_HUMAN	PF00433 (Pkinase_C) Protein kinase C terminal domain	992	1046		[mitab][xml]
(Q9NRM7) LATS2_HUMAN	PF00069 (Pkinase) Protein kinase domain				[mitab][xml]

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000691:

Phosphorylation of Yorkie homolog (YAP1) at S381 by Serine/threonine-protein kinase LATS1 (LATS1) (a key regulator of the Hippo Pathway) primes the sequence for phosphorylation by Casein kinase I isoform epsilon (CSNK1E) at S384 and S387. This targets YAP1 to the SCF ubiqutin ligase complex, F-box/WD repeat-containing protein 1A (BTRC), which marks is YAP1 for subsequent degradation by the proteasomal system. N.B. Serine/threonine-protein kinase LATS2 (LATS2) can replace LATS1 and Casein kinase I isoform delta (CSNK1D) can replace CSNK1E

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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