The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI003847 P31749 AKT1
AKT1_HUMAN
126 132 FRSGSPSDNSGAEEMEVSLA TP --- Homo sapiens (Human) 480

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0005 alanine scanning in vivo/in vitro/in silico Di Maira,2005 support certain FeatureDetection
experimental MI:0113 western blot in vitro Di Maira,2005 support certain ParticipantIdentification FeatureDetection
experimental MI:0424 protein kinase assay in vitro Di Maira,2005 support certain InteractionDetection
experimental MI:0424 protein kinase assay in vivo Di Maira,2005 support certain InteractionDetection
experimental MI:0427 Identification by mass spectrometry Di Maira,2005 support certain ParticipantIdentification

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P68400) CSK21_HUMAN PF00069 (Pkinase)
Protein kinase domain
39 324 [mitab][xml]

o  Pathways

KEGG: The sequence P31749 is implicated in the following 99 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM — the eukaryotic linear motif resource in 2020. (PMID:31680160)

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