The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI003249 Q16665 HIF1A
HIF1A_HUMAN
665 671 YRDTQSRTASPNRAGKGVIE TP --- Homo sapiens (Human) 826

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0096 pull down in vivo/in vitro support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Warfel,2013 support certain
experimental MI:0005 alanine scanning in vivo/in vitro/in silico Warfel,2013 support certain FeatureDetection
experimental MI:0424 protein kinase assay in vitro Warfel,2013 support certain InteractionDetection
experimental MI:0424 protein kinase assay in vivo Warfel,2013 support certain InteractionDetection
experimental MI:0113 western blot in vitro Warfel,2013 support certain ParticipantIdentification FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P06493) CDK1_HUMAN PF00069 (Pkinase)
Protein kinase domain
4 287 [mitab][xml]

o  Pathways

The sequence Q16665 is implicated in the following 8 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

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