The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI003247 P25054 APC
APC_HUMAN
1357 1363 AVEFSSGAKSPSKSGAQTPK TP --- Homo sapiens (Human) 2843

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0424 protein kinase assay in vitro Beamish,2009 support certain InteractionDetection
experimental MI:0005 alanine scanning in vivo/in vitro/in silico Beamish,2009 support certain FeatureDetection
experimental MI:0074 mutation analysis in vivo/in vitro Beamish,2009 support certain FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Beamish,2009 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P24941) CDK2_HUMAN PF00069 (Pkinase)
Protein kinase domain
4 286 [mitab][xml]

o  Pathways

The sequence P25054 is implicated in the following 10 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
feedback@elm.eu.org