ELM - instance LIG_WW_1 in sequence Q4VCS5 at position 239

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002438	Q4VCS5 AMOT AMOT_HUMAN	239	242	KGMEHRGPPPEYPFKGMPPQ	TP	---	Homo sapiens (Human)	1084

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0096	pull down	in vivo/in vitro		support	certain	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Zhao,2011	support	certain
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Zhao,2011	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Zhao,2011	support	certain	FeatureDetection

Switches

This ELM instance is part of the following 3 switching mechanisms annotated at the switches.ELM resource:

SWTI000463:

Alternative splicing removes the WW-binding motif of Angiomotin (AMOT), abrogating binding to Yorkie homolog (YAP1). The splice specific Isoform p130 of AMOT works within the Hippo pathway to sequester the transcription coactivator YAP1 away at tight junction. In contrast Isoform p80 of AMOT lacks WW-binding motif.
SWTI000464:

Alternative splicing removes the WW-binding motif of Angiomotin (AMOT), abrogating binding to WW domain-containing transcription regulator protein 1 (WWTR1). The splice specific Isoform p130 of AMOT works within the Hippo pathway to sequester the transcription coactivator YAP1 away at tight junction. In contrast Isoform p80 of AMOT lacks WW-binding motif.
SWTI000658:

Alternative splicing removes the WW-binding motif of Angiomotin (AMOT), abrogating binding to Yorkie homolog (YAP1). The splice specific Isoform p130 of AMOT works within the Hippo pathway to sequester the transcription coactivator YAP1 away at tight junction. In contrast Isoform p80 of AMOT lacks WW-binding motif.

Pathways

KEGG: The sequence Q4VCS5 is implicated in the following 2 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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