| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI002457 | P05627 Jun JUN_MOUSE |
167 | 170 | YSASLHSEPPVYANLSNFNP | TP | --- | Mus musculus (House mouse) | 334 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0997 | ubiquitinase assay | in vitro | Gao,2006 | support | certain | InteractionDetection |
| experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Gao,2006 | support | certain | InteractionDetection |
| experimental | MI:0997 | ubiquitinase assay | in vitro | Fang,2004 | support | certain | InteractionDetection |
| experimental | MI:0403 | colocalization | in vitro | Fang,2004 | support | certain | |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Fang,2004 | support | certain | FeatureDetection |
| experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Fang,2002 | support | certain | InteractionDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (Q8C863) ITCH_MOUSE | PF00397
(WW)
WW domain |
[mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000684:
Phosphorylation of Y170 in the WW-binding motif of Transcription factor AP-1 (Jun) by Tyrosine-protein kinase ABL1 (Abl1) blocks binding to the E3 ubiquitin-protein ligase Itchy (Itch). As a result, Transcription factor AP-1 (Jun) is not ubiquitylated by E3 ubiquitin-protein ligase Itchy (Itch), and thus not targeted for proteasomal degradation. Regulation of transcriptional activity of Transcription factor AP-1 (Jun) by Tyrosine-protein kinase ABL1 (Abl1) required translocation of the kinase to the nucleus, which was triggered by T cell activation.
Pathways
- AGE RAGE signaling pathway in diabetic complications
- Amphetamine addiction
- Apoptosis
- B cell receptor signaling pathway
- Breast cancer
- C type lectin receptor signaling pathway
- Chagas disease
- Chemical carcinogenesis reactive oxygen species
- Chemical carcinogenesis receptor activation
- Choline metabolism in cancer
- Cocaine addiction
- Colorectal cancer
- Coronavirus disease COVID 19
- Endocrine resistance
- Epstein Barr virus infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- GnRH signaling pathway
- Hepatitis B
- Human T cell leukemia virus 1 infection
- Human immunodeficiency virus 1 infection
- IL 17 signaling pathway
- Inflammatory bowel disease
- Kaposi sarcoma associated herpesvirus infection
- Leishmaniasis
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- Mitophagy animal
- NOD like receptor signaling pathway
- Neurotrophin signaling pathway
- Non alcoholic fatty liver disease
- Osteoclast differentiation
- Oxytocin signaling pathway
- PD L1 expression and PD 1 checkpoint pathway in cancer
- Pathways in cancer
- Pertussis
- Relaxin signaling pathway
- Renal cell carcinoma
- Rheumatoid arthritis
- Salmonella infection
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Tight junction
- Toll like receptor signaling pathway
- Viral carcinogenesis
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement