ELM - instance LIG_WD40_WDR5_WIN_1 in sequence Q03164 at position 3763

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002645	Q03164 MLL MLL1_HUMAN	3763	3769	PLNPHGSARAEVHLRKSAFD	TP	3EMH 4ESG	Homo sapiens (Human)	3969

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0065	isothermal titration calorimetry	in vitro	Dharmarajan,2012	support	certain	InteractionDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Dharmarajan,2012	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Dharmarajan,2012	support	certain	FeatureDetection
experimental	MI:0114	x-ray crystallography	in vitro	Dharmarajan,2012	support	certain	InteractionDetection FeatureDetection
experimental	MI:0065	isothermal titration calorimetry	in vitro	Zhang,2012	support	certain	InteractionDetection
experimental	MI:0405	competition binding	in vitro	Song,2008	support	certain	InteractionDetection
experimental	MI:0107	surface plasmon resonance	in vitro	Song,2008	support	certain	InteractionDetection FeatureDetection
experimental	MI:0114	x-ray crystallography	in vitro	Song,2008	support	certain	InteractionDetection FeatureDetection
experimental	MI:0096	pull down	in vivo/in vitro	Song,2008	support	certain	InteractionDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(P61964) WDR5_HUMAN	IPR017986 (IPR017986) WD40-repeat-containing domain	33	331	2.424/3.1	[mitab][xml]

Pathways

KEGG: The sequence Q03164 is implicated in the following 4 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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