| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI002646 | O14686 MLL2 MLL2_HUMAN |
5338 | 5344 | MINPTGCARSEPKILTHYKR | TP |
3UVK 
4ERQ 
|
Homo sapiens (Human) | 5537 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0065 | isothermal titration calorimetry | in vitro | Dharmarajan,2012 | support | certain | InteractionDetection |
| experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Dharmarajan,2012 | support | certain | InteractionDetection |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Dharmarajan,2012 | support | certain | FeatureDetection |
| experimental | MI:0114 | x-ray crystallography | in vitro | Dharmarajan,2012 | support | certain | InteractionDetection FeatureDetection |
| experimental | MI:0065 | isothermal titration calorimetry | in vitro | Zhang,2012 | support | certain | InteractionDetection |
| experimental | MI:0114 | x-ray crystallography | in vitro | Zhang,2012 | support | certain | InteractionDetection FeatureDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (P61964) WDR5_HUMAN | IPR017986
(IPR017986)
WD40-repeat-containing domain |
33 | 331 | 0.07/0.08 | [mitab][xml] |
Pathways
Diseases
- Sequence Variation VAR_063833 (Pos 5340) has been implicated in Kabuki Syndrome 1; Kabuk1 (OMIM:147920).
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement