The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI002646 O14686 MLL2
MLL2_HUMAN
5338 5344 MINPTGCARSEPKILTHYKR TP 3UVK  
pdb:3UVK 4ERQ  
pdb:4ERQ
Homo sapiens (Human) 5537

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0065 isothermal titration calorimetry in vitro Dharmarajan,2012 support certain InteractionDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Dharmarajan,2012 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Dharmarajan,2012 support certain FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Dharmarajan,2012 support certain InteractionDetection FeatureDetection
experimental MI:0065 isothermal titration calorimetry in vitro Zhang,2012 support certain InteractionDetection
experimental MI:0114 x-ray crystallography in vitro Zhang,2012 support certain InteractionDetection FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P61964) WDR5_HUMAN IPR017986 (IPR017986)
WD40-repeat-containing domain
33 331 0.07/0.08 [mitab][xml]

o  Pathways

The sequence O14686 is implicated in the following 1 Pathway: (color codes: This sequence=red, interacting sequence=orange)

o  Diseases

  • Sequence Variation VAR_063833 (Pos 5340) has been implicated in Kabuki Syndrome 1; Kabuk1 (OMIM:147920).
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

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