The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004500 Q7Z434 MAVS
MAVS_HUMAN
453 461 GMGPCHGPEENEYKSEGTFG TP 4Z8M  
Homo sapiens (Human) 540

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0074 mutation analysis in vivo/in vitro Xu,2005 support certain FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Xu,2005 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Shi,2015 support certain FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Shi,2015 support certain InteractionDetection FeatureDetection
experimental MI:0969 biolayer interferometry Shi,2015 support certain InteractionDetection
experimental MI:0096 pull down in vivo/in vitro Shi,2015 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q9Y4K3) TRAF6_HUMAN IPR037309 (TNF receptor-associated factor 6, MATH domain)
TNF receptor-associated factor 6 (TRAF6) regulates a diverse array of processes, including adaptive immunity, innate immunity, bone metabolism and tissue development
351 500 0.036/0.036 [mitab][xml]

o  Pathways

KEGG: The sequence Q7Z434 is implicated in the following 10 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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