ELM - instance LIG_SUMO_SIM_par_1 in sequence O75928 at position 468

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002771	O75928 PIAS2 PIAS2_HUMAN	468	473	EASKKKVDVIDLTIESSSDE	TP	2ASQ	Homo sapiens (Human)	621

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0077	nuclear magnetic resonance	in vitro	Hecker,2006	support	certain	InteractionDetection FeatureDetection
experimental	MI:0077	nuclear magnetic resonance	in vitro	Song,2004	support	certain	InteractionDetection FeatureDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Song,2005	support	certain	FeatureDetection
experimental	MI:0005	alanine scanning	in vivo/in vitro/in silico	Song,2005	support	certain	FeatureDetection
experimental	MI:0077	nuclear magnetic resonance	in vitro	Song,2005	support	certain	InteractionDetection FeatureDetection
experimental	MI:0065	isothermal titration calorimetry	in vitro	Song,2005	support	certain	InteractionDetection

Switches

This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:

SWTI000664:

Acetylation of K33 in Small ubiquitin-related modifier 2 (SUMO2) inhibits binding to E3 SUMO-protein ligase PIAS2 (PIAS2). The acetylation counters SUMO-SIM-dependent transcriptional repression processes. An additional interaction is also possible upon acetylation with the Bromodomain of p300 shown to bind the acetylated version of SUMO2. This does not occur with acetylated SUMO1. Acetylation is countered by Histone deacetylase family, HD type 1 subfamily.
SWTI000665:

Acetylation of K37 in Small ubiquitin-related modifier 1 (SUMO1) inhibits binding to E3 SUMO-protein ligase PIAS2 (PIAS2). The acetylation counters SUMO-SIM-dependent transcriptional repression processes. Acetylation is countered by Histone deacetylase family, HD type 1 subfamily.

Pathways

KEGG: The sequence O75928 is implicated in the following 2 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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