Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
---|---|---|---|---|---|---|---|---|
ELMI002771 | O75928 PIAS2 PIAS2_HUMAN |
468 | 473 | EASKKKVDVIDLTIESSSDE | TP |
2ASQ |
Homo sapiens (Human) | 621 |
Instance evidence
Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
---|---|---|---|---|---|---|---|
experimental | MI:0077 | nuclear magnetic resonance | in vitro | Hecker,2006 | support | certain | InteractionDetection FeatureDetection |
experimental | MI:0077 | nuclear magnetic resonance | in vitro | Song,2004 | support | certain | InteractionDetection FeatureDetection |
experimental | MI:0074 | mutation analysis | in vivo/in vitro | Song,2005 | support | certain | FeatureDetection |
experimental | MI:0005 | alanine scanning | in vivo/in vitro/in silico | Song,2005 | support | certain | FeatureDetection |
experimental | MI:0077 | nuclear magnetic resonance | in vitro | Song,2005 | support | certain | InteractionDetection FeatureDetection |
experimental | MI:0065 | isothermal titration calorimetry | in vitro | Song,2005 | support | certain | InteractionDetection |
Switches
This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:
-
SWTI000664:
Acetylation of K33 in Small ubiquitin-related modifier 2 (SUMO2) inhibits binding to E3 SUMO-protein ligase PIAS2 (PIAS2). The acetylation counters SUMO-SIM-dependent transcriptional repression processes. An additional interaction is also possible upon acetylation with the Bromodomain of p300 shown to bind the acetylated version of SUMO2. This does not occur with acetylated SUMO1. Acetylation is countered by Histone deacetylase family, HD type 1 subfamily.
-
SWTI000665:
Acetylation of K37 in Small ubiquitin-related modifier 1 (SUMO1) inhibits binding to E3 SUMO-protein ligase PIAS2 (PIAS2). The acetylation counters SUMO-SIM-dependent transcriptional repression processes. Acetylation is countered by Histone deacetylase family, HD type 1 subfamily.
Pathways
KEGG: The sequence O75928 is implicated in the following 2 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite:
The Eukaryotic Linear Motif resource: 2022 release.
(PMID:34718738)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement