The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI002625 P08151 GLI1
GLI1_HUMAN
120 127 CTSPGGSYGHLSIGTMSPSL TP 4BLB  
pdb:4BLB 4KMD  
pdb:4KMD
Homo sapiens (Human) 1106

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0096 pull down in vivo/in vitro support certain InteractionDetection
experimental MI:0521 his tag in vivo/in vitro/in silico Zhang,2013 support certain
experimental MI:0065 isothermal titration calorimetry in vitro Zhang,2013 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Zhang,2013 support certain FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Zhang,2013 support certain InteractionDetection FeatureDetection
experimental MI:1247 microscale thermophoresis in vitro Cherry,2013 support certain InteractionDetection
experimental MI:0007 anti tag coimmunoprecipitation in vivo Cherry,2013 support certain InteractionDetection
experimental MI:0114 x-ray crystallography in vitro Cherry,2013 support certain InteractionDetection FeatureDetection
experimental MI:0005 alanine scanning in vivo/in vitro/in silico Dunaeva,2003 support certain FeatureDetection
experimental MI:0074 mutation analysis in vivo/in vitro Dunaeva,2003 support certain FeatureDetection
experimental MI:0113 western blot in vitro Dunaeva,2003 support certain ParticipantIdentification FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Dunaeva,2003 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q9UMX1) SUFU_HUMAN PF05076 (SUFU)
Suppressor of fused protein (SUFU)
63 242 1.59/2.33 [mitab][xml]
(Q9UMX1) SUFU_HUMAN PF12470 (SUFU_C)
Suppressor of Fused Gli/Ci N terminal binding domain
252 473 1.59/2.33 [mitab][xml]

o  Pathways

KEGG: The sequence P08151 is implicated in the following 4 Pathways: (color codes: This sequence=red, interacting sequence=orange) Reactome: The sequence P08151 is implicated in the following 4 Pathways:
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

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