ELM - instance LIG_SH3_PxxxRxxKP_6 in sequence Q13480 at position 517

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI004782	Q13480 GAB1 GAB1_HUMAN	517	525	ADCEPPPVDRNLKPDRKVKP	TP	---	Homo sapiens (Human)	694

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0065	isothermal titration calorimetry	in vitro	Harkiolaki,2003	support	certain	InteractionDetection
experimental	MI:0018	two hybrid	in vivo	Lewitzky,2001	support	certain	InteractionDetection
experimental	MI:0405	competition binding	in vitro	Lewitzky,2001	support	certain	InteractionDetection
experimental	MI:0017	classical fluorescence spectroscopy	in vitro	Lewitzky,2001	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Lewitzky,2001	support	certain	FeatureDetection
experimental	MI:0033	deletion analysis		Lewitzky,2001	support	certain	FeatureDetection
experimental	MI:0096	pull down	in vivo/in vitro	Lewitzky,2001	support	certain	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Lewitzky,2001	support	certain
experimental	MI:0113	western blot	in vitro	Schaeper,2000	support	certain	ParticipantIdentification FeatureDetection
experimental	MI:0007	anti tag coimmunoprecipitation	in vivo	Schaeper,2000	support	certain	InteractionDetection
experimental	MI:0018	two hybrid	in vivo	Schaeper,2000	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Schaeper,2000	support	certain	FeatureDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(O75791) GRAP2_HUMAN	IPR001452 (SH3 domain) SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues	271	330	0.603/0.603	[mitab][xml]
(P62993) GRB2_HUMAN	IPR001452 (SH3 domain) SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues	156	215	10.04/11.82	[mitab][xml]

Pathways

KEGG: The sequence Q13480 is implicated in the following 10 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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