The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004799 P70218 Map4k1
M4K1_MOUSE
467 476 PEPGQPPLVPPRKEKMRGKM TP 1UTI  
Mus musculus (House mouse) 827

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0005 alanine scanning in vivo/in vitro/in silico Lewitzky,2004 support certain FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Lewitzky,2004 support certain InteractionDetection FeatureDetection
experimental MI:0033 deletion analysis Lewitzky,2004 support certain FeatureDetection
experimental MI:0074 mutation analysis in vivo/in vitro Lewitzky,2004 support certain FeatureDetection
experimental MI:0065 isothermal titration calorimetry in vitro Lewitzky,2004 support certain InteractionDetection
experimental MI:1088 phenotype-based detection assay Liu,2000 support certain InteractionDetection
experimental MI:0096 pull down in vivo/in vitro Liu,2000 support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Liu,2000 support certain
experimental MI:0074 mutation analysis in vivo/in vitro Liu,2000 support certain FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Liu,2000 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(O75791) GRAP2_HUMAN IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues
271 330 2.4/2.4 [mitab][xml]
(O89100) GRAP2_MOUSE IPR001452 (SH3 domain)
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues
263 322 [mitab][xml]
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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