The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004429 P22681 CBL
CBL_HUMAN
824 829 SQVPERPPKPFPRRINSERK TP --- Homo sapiens (Human) 906

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0077 nuclear magnetic resonance in vitro Ababou,2009 support certain InteractionDetection FeatureDetection
experimental MI:0065 isothermal titration calorimetry in vitro Ababou,2009 support certain InteractionDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Jozic,2005 support likely InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Jozic,2005 support likely FeatureDetection
experimental MI:0074 mutation analysis in vivo/in vitro Kowanetz,2003 support likely FeatureDetection
experimental MI:0113 western blot in vitro Kowanetz,2003 support likely ParticipantIdentification FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Kowanetz,2003 support likely InteractionDetection
experimental MI:0065 isothermal titration calorimetry in vitro Kowanetz,2003 support likely InteractionDetection
experimental MI:0403 colocalization in vitro Watanabe,2000 support likely
experimental MI:0007 anti tag coimmunoprecipitation in vivo Watanabe,2000 support likely InteractionDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Kirsch,2001 support certain InteractionDetection
experimental MI:0051 fluorescence technology Kirsch,2001 support certain InteractionDetection
experimental MI:0403 colocalization in vitro Kirsch,2001 support certain
experimental MI:0004 affinity chromatography technology in vivo/in vitro Kirsch,2001 support certain InteractionDetection
experimental MI:0007 anti tag coimmunoprecipitation in vivo Take,2000 support certain InteractionDetection
experimental MI:0018 two hybrid in vivo Take,2000 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q9Y5K6) CD2AP_HUMAN PF14604 (SH3_9)
Variant SH3 domain
115 163 [mitab][xml]
(Q96B97) SH3K1_HUMAN PF14604 (SH3_9)
Variant SH3 domain
6 54 6.3/6.3 [mitab][xml]
(Q96B97) SH3K1_HUMAN PF14604 (SH3_9)
Variant SH3 domain
105 153 4.38/5.48 [mitab][xml]
(Q96B97) SH3K1_HUMAN PF14604 (SH3_9)
Variant SH3 domain
274 324 [mitab][xml]

o  Pathways

KEGG: The sequence P22681 is implicated in the following 8 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM — the eukaryotic linear motif resource in 2020. (PMID:31680160)

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