ELM - instance LIG_SH3_CIN85_PxpxPR_1 in sequence P22681 at position 824

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI004429	P22681 CBL CBL_HUMAN	824	829	SQVPERPPKPFPRRINSERK	TP	---	Homo sapiens (Human)	906

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0077	nuclear magnetic resonance	in vitro	Ababou,2009	support	certain	InteractionDetection FeatureDetection
experimental	MI:0065	isothermal titration calorimetry	in vitro	Ababou,2009	support	certain	InteractionDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Jozic,2005	support	likely	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Jozic,2005	support	likely	FeatureDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Kowanetz,2003	support	likely	FeatureDetection
experimental	MI:0113	western blot	in vitro	Kowanetz,2003	support	likely	ParticipantIdentification FeatureDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Kowanetz,2003	support	likely	InteractionDetection
experimental	MI:0065	isothermal titration calorimetry	in vitro	Kowanetz,2003	support	likely	InteractionDetection
experimental	MI:0403	colocalization	in vitro	Watanabe,2000	support	likely
experimental	MI:0007	anti tag coimmunoprecipitation	in vivo	Watanabe,2000	support	likely	InteractionDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Kirsch,2001	support	certain	InteractionDetection
experimental	MI:0051	fluorescence technology		Kirsch,2001	support	certain	InteractionDetection
experimental	MI:0403	colocalization	in vitro	Kirsch,2001	support	certain
experimental	MI:0004	affinity chromatography technology	in vivo/in vitro	Kirsch,2001	support	certain	InteractionDetection
experimental	MI:0007	anti tag coimmunoprecipitation	in vivo	Take,2000	support	certain	InteractionDetection
experimental	MI:0018	two hybrid	in vivo	Take,2000	support	certain	InteractionDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(Q9Y5K6) CD2AP_HUMAN	PF14604 (SH3_9) Variant SH3 domain	115	163		[mitab][xml]
(Q96B97) SH3K1_HUMAN	PF14604 (SH3_9) Variant SH3 domain	6	54	6.3/6.3	[mitab][xml]
(Q96B97) SH3K1_HUMAN	PF14604 (SH3_9) Variant SH3 domain	105	153	4.38/5.48	[mitab][xml]
(Q96B97) SH3K1_HUMAN	PF14604 (SH3_9) Variant SH3 domain	274	324		[mitab][xml]

Pathways

KEGG: The sequence P22681 is implicated in the following 8 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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