ELM - instance LIG_SH2_SFK_2 in sequence Q14289 at position 400

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI004897	Q14289 PTK2B FAK2_HUMAN	400	408	CSIESDIYAEIPDETLRRPG	TP	---	Homo sapiens (Human)	1009

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0074	mutation analysis	in vivo/in vitro	Katagiri,2000	support	certain	FeatureDetection
experimental	MI:0096	pull down	in vivo/in vitro	Katagiri,2000	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Sanjay,2001	support	certain	FeatureDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Sanjay,2001	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Kumar,1999	support	certain	FeatureDetection
experimental	MI:0096	pull down	in vivo/in vitro	Kumar,1999	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Dikic,1996	support	certain	FeatureDetection
experimental	MI:0096	pull down	in vivo/in vitro	Dikic,1996	support	certain	InteractionDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(P06241) FYN_HUMAN	IPR000980 (SH2 domain) The Src homology 2 (SH2) domain is a protein domain of about 100 amino-acid residues first identified as a conserved sequence region between the oncoproteins Src and Fps	146	246		[mitab][xml]
(P12931) SRC_HUMAN	IPR000980 (SH2 domain) The Src homology 2 (SH2) domain is a protein domain of about 100 amino-acid residues first identified as a conserved sequence region between the oncoproteins Src and Fps	149	248		[mitab][xml]

Pathways

KEGG: The sequence Q14289 is implicated in the following 10 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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